Hoxd3 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including glossopharyngeal nerve morphogenesis; skeletal system development; and thyroid gland development. Predicted to be located in aggresome and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HOXD3 (homeobox D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxd3 |
| Official Name | homeobox D3 [Source:MGI Symbol;Acc:MGI:96207] |
| Ensembl ID | ENSMUSG00000079277 |
| Bio databases IDs | |
| Aliases | homeobox D3 |
| Synonyms | homeo box D3, HOX1D, HOX4, Hox-4.1, HOX4A, Hox4r6, Hox-5.5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Domain of unknown function (DUF4074)
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxd3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motion sickness
- endometriosis
- glioblastoma
- glioblastoma cancer
- glossopharyngeal-vagus nerve fusion
- glioma formation
- preeclampsia
- pelvic organ prolapse
- low-grade glioma
role in cell
- expression in
- proliferation
- differentiation
- neurite outgrowth in
- repression in
- adhesion
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- transcription, DNA-dependent
- glossopharyngeal nerve morphogenesis
- anterior/posterior pattern specification
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- thyroid gland development
- positive regulation of gene expression
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity