Nrg2 Gene Summary [Mouse]
Enables receptor ligand activity. Involved in ERBB2-ERBB3 signaling pathway and ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrg2 |
| Official Name | neuregulin 2 [Source:MGI Symbol;Acc:MGI:1098246] |
| Ensembl ID | ENSMUSG00000060275 |
| Bio databases IDs | |
| Aliases | neuregulin 2 |
| Synonyms | DON1, HRG2, LOC100045947, neuregulin 2, NTAK, NTAK alpha1, NTAK alpha2a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuregulin intracellular region
- immunoglobulin domain
- epidermal growth factor receptor binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- receptor agonist activity
- receptor binding
- EGF-like domain
- growth factor
Pathways
Biological processes and signaling networks where the Nrg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- schizophrenia
role in cell
- growth
- quantity
- phosphorylation in
- proliferation
- apoptosis
- maturation
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
- organ development
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- receptor binding