Hoxa3 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and HMG box domain binding activity. Acts upstream of or within several processes, including endocrine system development; regionalization; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; gut; and nervous system. Used to study DiGeorge syndrome. Orthologous to human HOXA3 (homeobox A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa3 |
| Official Name | homeobox A3 [Source:MGI Symbol;Acc:MGI:96175] |
| Ensembl ID | ENSMUSG00000079560 |
| Bio databases IDs | |
| Aliases | homeobox A3 |
| Synonyms | homeobox A3, HOX1, Hox-1.5, HOX1E, LOC100911474, LOC108348320, Mo-10, RGD1561431 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Domain of unknown function (DUF4074)
- protein domain specific binding
- protein binding
- transcription factor activity
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxa3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- hypospadia
- glossopharyngeal-vagus nerve fusion
- hypoplasia
- persistent truncus arteriosus
- laryngostenosis
- bicuspid pulmonary valve
- stenosis
- rotator cuff injury
role in cell
- phosphorylation in
- proliferation
- expression in
- apoptosis
- activation in
- differentiation
- quantity
- number
- M2 polarization
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glossopharyngeal nerve morphogenesis
- anterior/posterior pattern specification
- organ formation
- embryonic skeletal system morphogenesis
- parathyroid gland development
- regulation of transcription from RNA polymerase II promoter
- thymus development
- thyroid gland development
- blood vessel remodeling
- angiogenesis
- positive regulation of stem cell proliferation
- stem cell proliferation
- specification of organ position
- gene expression
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity