CCL20

CCL20 Gene Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Details

Type
Protein Coding
Official Symbol
CCL20
Official Name
C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619]
Ensembl ID
ENSG00000115009
Bio databases IDs NCBI: 6364 Ensembl: ENSG00000115009
Aliases C-C motif chemokine ligand 20
Synonyms
C-C motif chemokine ligand 20,CHEMOKINE EXUDUS 1,CKb4,Exodus,exodus-1,LARC,Mip3,MIP-3A,MIP-3[a],MIP-3-alpha,MIP-3-α,SCYA20,ST38
Species
Human, homo_sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • CCR chemokine receptor binding
  • chemokine
  • Small cytokines (intecrine/chemokine), interleukin-8 like
  • protein binding
  • cytokine

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • SP3
  • CCR6
  • HNF4A
  • NR2C2
  • CXCL12
  • NFKB1
  • TIMP2
  • SMAD4
  • RELA
  • RALBP1
disease
  • diabetic nephropathy
  • neoplasia
  • hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • COVID-19
  • atopic dermatitis
  • pancreatic ductal adenocarcinoma
  • pancreatic epithelial cancer
  • ductal pancreatic cancer
regulated by
  • palmitic acid
  • D-glucose
  • sirolimus
  • tretinoin
  • Caco2 cells
  • AQP3
  • IL17A
  • KRT17
  • CTSD
  • IL1B
regulates
  • EGFR
  • MAPK
  • AKT
  • Ca2+
  • NLRP3
  • CASP1
  • COL1A1
  • CDH1
  • SYK
  • CCL20
role in cell
  • production in
  • expression in
  • phosphorylation in
  • activation in
  • proliferation
  • quantity
  • migration
  • adhesion
  • activation
  • chemotaxis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • detergent resistant lipid raft fraction
  • Cytoplasm
  • cell surface
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CCL20 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • signal transduction
  • cell-cell signaling
  • defense response to bacterium
  • positive regulation of GTPase activity
  • cell chemotaxis
  • positive regulation of T cell migration
  • chemotaxis
  • inflammatory response
  • immune response
  • chemokine-mediated signaling pathway
  • thymocyte migration
  • T cell migration
  • calcium-mediated signaling
  • positive regulation of cell migration

CELLULAR COMPONENT

Where in the cell the gene product is active
  • extracellular space
  • extracellular region

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • CCR chemokine receptor binding
  • chemokine activity
  • CCR6 chemokine receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.