Ddah1 Gene Summary [Mouse]
Enables dimethylargininase activity. Involved in positive regulation of nitric oxide biosynthetic process and regulation of systemic arterial blood pressure. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; future prosencephalon; retina; and spinal cord. Human ortholog(s) of this gene implicated in cardiovascular system disease; coronary artery disease; and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddah1 |
| Official Name | dimethylarginine dimethylaminohydrolase 1 [Source:MGI Symbol;Acc:MGI:1916469] |
| Ensembl ID | ENSMUSG00000028194 |
| Bio databases IDs | |
| Aliases | dimethylarginine dimethylaminohydrolase 1 |
| Synonyms | 2410006N07Rik, 2510015N06Rik, DDAH, DDAHI, Dimethylargininase, dimethylarginine dimethylaminohydrolase 1, HEL-S-16, N-GN-G-dimethylarginine dimethylaminohydrolase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddah1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- enzyme
- dimethylargininase
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- Alzheimer disease
- experimentally-induced diabetes
- multiple sclerosis
- rotator cuff injury
- lung injury
- eosinophilic esophagitis
role in cell
- proliferation
- formation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddah1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arginine catabolic process
- positive regulation of nitric oxide biosynthetic process
- arginine metabolic process
- citrulline metabolic process
- nitric oxide mediated signal transduction
- negative regulation of cell proliferation
- regulation of systemic arterial blood pressure
- negative regulation of cellular response to hypoxia
- negative regulation of vascular permeability
- nitric oxide metabolic process
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- dimethylargininase activity
- catalytic activity
- metal ion binding
- amino acid binding