Yars Gene Summary [Mouse]
Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation and tyrosyl-tRNA aminoacylation. Predicted to be located in nuclear body. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Charcot-Marie-Tooth disease dominant intermediate C. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Yars |
| Official Name | tyrosyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2147627] |
| Ensembl ID | ENSMUSG00000028811 |
| Bio databases IDs | |
| Aliases | tyrosyl-tRNA synthetase |
| Synonyms | CMTDIC, IMNEPD2, tyrosyl-tRNA synthetase 1, TYRRS, tyrS, YARS, YRS, YTS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Yars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA synthetases class I (W and Y)
- tyrosine-tRNA ligase
- methionyl-tRNA synthetase C-terminal region/beta chain
- enzyme
- protein binding
- tRNA_bindingDomain
- ELR motif
- tyrosyl-tRNA synthetase
- interleukin-8 receptor binding
- binding protein
- tryptophanyl-tRNA synthetase
- Putative tRNA binding domain
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- infantile-onset multisystem neurologic, endocrine, and pancreatic disease type 2
- Charcot-Marie-Tooth disease, dominant intermediate type c
- infantile-onset multisystem neurologic, endocrine and pancreatic disease
- small cell lung cancer
- acute myeloid leukemia
- Charcot-Marie-Tooth disease
- hereditary disorder
- non-small cell lung cancer
role in cell
- growth
- cell death
- migration
- phosphorylation in
- apoptosis
- activation in
- formation
- length
- chemotaxis
- tubulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- granules
- cytosol
- nuclear bodies
- neurites
- filopodia
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Yars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tyrosyl-tRNA aminoacylation
- apoptotic process
- response to starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- nuclear body
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- tyrosine-tRNA ligase activity
- ATP binding
- RNA binding
- protein binding
- interleukin-8 receptor binding
- small molecule binding
- tRNA binding