Sap18 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Predicted to be involved in positive regulation of apoptotic process and regulation of RNA metabolic process. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear speck. Predicted to be part of ASAP complex; nucleus; and transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; limb; and sensory organ. Orthologous to human SAP18 (Sin3A associated protein 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sap18 |
| Official Name | Sin3-associated polypeptide 18 [Source:MGI Symbol;Acc:MGI:1277978] |
| Ensembl ID | ENSMUSG00000021963 |
| Bio databases IDs | |
| Aliases | Sin3-associated polypeptide 18 |
| Synonyms | 2HOR0202, C530046K05Rik, D11Ertd539e, EMegR4, Sap18a, SAP18P, Sin3A associated protein 18, Sin3-associated polypeptide 18, Sinbp1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sap18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-repressor
- Sin3 associated polypeptide p18 (SAP18)
- protein binding
Pathways
Biological processes and signaling networks where the Sap18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- apoptosis
- cell death
- alternative splicing by
- splicing by
- alternative splicing in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- cytosol
- inner nuclear membrane
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sap18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of apoptotic process
- mRNA processing
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- nuclear body
- nuclear speck
- cytosol
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- transcription corepressor activity
- transcription factor binding