Bdnf Gene Summary [Mouse]
The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Bdnf |
| Official Name | brain derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:88145] |
| Ensembl ID | ENSMUSG00000048482 |
| Bio databases IDs | |
| Aliases | brain derived neurotrophic factor |
| Synonyms | ANON2, Brain derived neurotrophic factor, BULN2, OCD1, tBDNF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bdnf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- loop domain
- pro domain
- neurotrophin TRKB receptor binding
- growth factor
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Bdnf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- CDK5 Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Human Embryonic Stem Cell Pluripotency
- Huntington's Disease Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Neurotrophin/TRK Signaling
- PEDF Signaling
- Serotonin Receptor Signaling
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- cyclosporin A
- midazolam
- tetrachlorodibenzodioxin
- lovastatin
- fingolimod
- Ca2+
- PTEN
- FSH
- dopamine
- D-mannose
disease
- diarrhea
- plasma cell myeloma
- neoplasia
- weight loss
- liver cancer
- cancer
- epithelial cancer
- neurodegeneration
- obesity
- metabolic syndrome X
phenotypes
- abnormal CNS synaptic transmission
- abnormal GABAergic neuron morphology
- abnormal adrenergic neuron morphology
- abnormal axon pruning
- abnormal barrel cortex morphology
- abnormal brain interneuron morphology
- abnormal cerebellum external granule cell layer morphology
- abnormal circumvallate papillae morphology
- abnormal cochlea morphology
- abnormal cochlear OHC afferent innervation pattern
- abnormal cochlear ganglion morphology
- abnormal colon goblet cell morphology
- abnormal colon morphology
- abnormal contextual conditioning behavior
- abnormal cranial ganglia morphology
- abnormal crista ampullaris morphology
- abnormal dendrite morphology
- abnormal dendritic spine morphology
- abnormal dentate gyrus morphology
- abnormal dorsal root ganglion morphology
- abnormal excitatory postsynaptic potential
- abnormal fungiform papillae morphology
- abnormal geniculate ganglion morphology
- abnormal gustatory papillae taste bud morphology
- abnormal gustatory system morphology
- abnormal hair cycle
- abnormal inhibitory postsynaptic currents
- abnormal innervation
- abnormal intestine morphology
- abnormal keratinocyte morphology
- abnormal locomotor activation
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal nervous system electrophysiology
- abnormal nervous system physiology
- abnormal neuron apoptosis
- abnormal neuron differentiation
- abnormal neuron morphology
- abnormal neuron physiology
- abnormal sensory ganglion morphology
- abnormal sensory neuron innervation pattern
- abnormal sensory neuron morphology
- abnormal serotonergic neuron morphology
- abnormal serotonin level
- abnormal somatic nervous system morphology
- abnormal somatic sensory system morphology
- abnormal striatum morphology
- abnormal sympathetic system morphology
- abnormal synaptic plasticity
- abnormal trigeminal nerve morphology
- abnormal type I vestibular cell
- abnormal vestibular ganglion morphology
- abnormal vestibular nerve morphology
- ataxia
- circling
- deafness
- decreased body size
- decreased body weight
- decreased brain size
- decreased exploration in new environment
- decreased hippocampus volume
- decreased pulmonary respiratory rate
- decreased sensory neuron number
- decreased tongue size
- decreased vertical activity
- excessive scratching
- female infertility
- head bobbing
- head tilt
- hunched posture
- hyperactivity
- hypoactivity
- impaired balance
- impaired coordination
- impaired limb coordination
- impaired righting response
- impaired synaptic plasticity
- increased aggression towards males
- increased anxiety-related response
- increased body weight
- increased circulating insulin level
- increased neuron apoptosis
- increased neuron number
- increased susceptibility to age related obesity
- no abnormal phenotype detected
- obese
- polyphagia
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- reduced long term potentiation
- reduced male fertility
- shortened head
- small L4 dorsal root ganglion
- small dorsal root ganglion
- small geniculate ganglion
- small mesencephalic trigeminal nucleus
- small nodose ganglion
- small petrosal ganglion
- small trigeminal ganglion
- small vestibular ganglion
- spinning
- vestibular ganglion degeneration
- weight loss
role in cell
- growth
- cell viability
- synthesis in
- killing
- activation in
- formation
- formation in
- expression in
- apoptosis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- en passant terminal
- Cytoplasm
- cell surface
- intracellular space
- somatodendritic region
- perinuclear region
- Nucleus
- vesicles
- Golgi Apparatus
- granules
- endoplasmic reticulum lumen
- mitochondrial inner membrane
- perinuclear space
- alpha granules
- dendritic spine head
- synaptic vesicles
- neurites
- nerve ending
- dendrite initial segments
- synaptosomes
- synapse
- dense-core vesicles
- cytoplasmic vesicles
- secretory vesicles
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- mossy fiber boutons
- presynaptic terminals
- axon branches
- clathrin-coated vesicles
- cis Golgi cisternae
- mossy fibers
- apical processes
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bdnf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of receptor binding
- nervous system development
- neuron projection morphogenesis
- transmembrane receptor protein tyrosine kinase signaling pathway
- axon guidance
- collateral sprouting
- negative regulation of neuron apoptotic process
- nerve development
- positive regulation of collateral sprouting
- synapse assembly
- brain-derived neurotrophic factor receptor signaling pathway
- regulation of protein localization at cell surface
- regulation of synaptic transmission
- positive regulation of brain-derived neurotrophic factor receptor signaling pathway
- positive regulation of neuron projection development
- negative regulation of myotube differentiation
- positive regulation of synapse assembly
- negative regulation of apoptotic signaling pathway
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- endoplasmic reticulum lumen
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding