Dnmt3l Gene Summary [Rat]
Predicted to enable enzyme activator activity and enzyme binding activity. Involved in response to ethanol. Predicted to be located in condensed nuclear chromosome and heterochromatin. Predicted to be part of ESC/E(Z) complex. Predicted to be active in cytoplasm and nucleus. Biomarker of choline deficiency disease. Orthologous to human DNMT3L (DNA methyltransferase 3 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnmt3l |
| Official Name | DNA methyltransferase 3 like [Source:RGD Symbol;Acc:1303239] |
| Ensembl ID | ENSRNOG00000001212 |
| Bio databases IDs | |
| Aliases | DNA methyltransferase 3 like |
| Synonyms | D6Ertd14e, DNA methyltransferase 3-like, ecat7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnmt3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- transcription regulator
- nuclear localization sequence
- enzyme binding
- PHD finger superfamily
- protein binding
- enzyme activator activity
- Cysteine rich ADD domain in DNMT3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- liver cancer
- organismal death
- Vogt-Koyanagi-Harada disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- epithelial cancer in situ
- lung squamous cell carcinoma
role in cell
- expression in
- proliferation
- binding in
- differentiation
- meiosis I
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnmt3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression, epigenetic
- stem cell differentiation
- chorionic trophoblast cell differentiation
- spermatogenesis
- negative regulation of methylation-dependent chromatin silencing
- male meiosis I
- placenta development
- genetic imprinting
- methylation-dependent chromatin silencing
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- ESC/E(Z) complex
- cytosol
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
- enzyme activator activity
- enzyme binding