Cdk19 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Involved in cellular response to lipopolysaccharide and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk19 |
| Official Name | cyclin-dependent kinase 19 [Source:RGD Symbol;Acc:1305435] |
| Ensembl ID | ENSRNOG00000000583 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 19 |
| Synonyms | 2700084L06RIK, AI845279, bA346C16.3, CDC2L6, CDK11, CDK8L, cyclin-dependent kinase 19, DEE87, EIEE87, KIAA1028, mKIAA1028 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- Protein kinase domain
Pathways
Biological processes and signaling networks where the Cdk19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- developmental and epileptic encephalopathy type 87
- castration refractory prostate cancer
- endometrioma
- hereditary disorder
role in cell
- proliferation
- growth
- expression in
- number
- apoptosis
- mitosis
- upregulation in
- regulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- positive regulation of apoptotic process
- regulation of cell cycle
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity