Dnmt3l Gene Summary [Mouse]
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Dnmt3l |
| Official Name | DNA (cytosine-5-)-methyltransferase 3-like [Source:MGI Symbol;Acc:MGI:1859287] |
| Ensembl ID | ENSMUSG00000000730 |
| Bio databases IDs | |
| Aliases | DNA (cytosine-5-)-methyltransferase 3-like |
| Synonyms | D6Ertd14e, DNA methyltransferase 3-like, ecat7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnmt3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- transcription regulator
- nuclear localization sequence
- enzyme binding
- PHD finger superfamily
- protein binding
- enzyme activator activity
- Cysteine rich ADD domain in DNMT3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- liver cancer
- organismal death
- Vogt-Koyanagi-Harada disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- epithelial cancer in situ
- lung squamous cell carcinoma
role in cell
- expression in
- proliferation
- binding in
- differentiation
- meiosis I
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnmt3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression, epigenetic
- stem cell differentiation
- chorionic trophoblast cell differentiation
- spermatogenesis
- negative regulation of methylation-dependent chromatin silencing
- male meiosis I
- placenta development
- genetic imprinting
- methylation-dependent chromatin silencing
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- ESC/E(Z) complex
- cytosol
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
- enzyme activator activity
- enzyme binding