Ntf3 Gene Summary [Mouse]
This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ntf3 |
| Official Name | neurotrophin 3 [Source:MGI Symbol;Acc:MGI:97380] |
| Ensembl ID | ENSMUSG00000049107 |
| Bio databases IDs | |
| Aliases | neurotrophin 3 |
| Synonyms | AI316846, AI835689, HDNF, neurotrophin 3, NGF-2, NT-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotrophin p75 receptor binding
- Neutrophin-3 N-terminus
- chemoattractant
- protein binding
- receptor binding
- growth factor
- growth factor binding
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Ntf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- neurodegeneration
- Alzheimer disease
- motor dysfunction or movement disorder
- persistent truncus arteriosus
- ataxia
- heat hyperalgesia
- systemic lupus erythematosus
- insomnia
- neurological signs
phenotypes
- abnormal Merkel's receptor morphology
- abnormal atrioventricular valve morphology
- abnormal atrium myocardial trabeculae morphology
- abnormal blood vessel morphology
- abnormal cardiovascular system morphology
- abnormal cardiovascular system physiology
- abnormal cranial ganglia morphology
- abnormal cutaneous/subcutaneous mechanoreceptor morphology
- abnormal dorsal root ganglion morphology
- abnormal estrous cycle
- abnormal food intake
- abnormal heart development
- abnormal heart left ventricle size
- abnormal heart morphology
- abnormal heart valve morphology
- abnormal heart ventricle morphology
- abnormal heart ventricle outflow tract morphology
- abnormal innervation
- abnormal innervation pattern to muscle
- abnormal limb posture
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal muscle morphology
- abnormal muscle spindle morphology
- abnormal noradrenaline level
- abnormal posture
- abnormal proprioceptive neuron morphology
- abnormal pulmonary vein morphology
- abnormal semilunar valve morphology
- abnormal sensory capabilities/reflexes/nociception
- abnormal sensory ganglion morphology
- abnormal sensory neuron innervation pattern
- abnormal sensory neuron morphology
- abnormal sinus venosus morphology
- abnormal somatic nervous system morphology
- abnormal stellate ganglion morphology
- abnormal suckling behavior
- abnormal vestibulocochlear ganglion morphology
- absent golgi tendon organ
- absent muscle spindles
- absent proprioceptive neurons
- aneurysm
- anomalous pulmonary venous connection
- ataxia
- athetotic walking movements
- atrium myocardium hypoplasia
- cardiac hypertrophy
- cochlear ganglion hypoplasia
- decreased body size
- decreased body weight
- decreased heart rate
- decreased motor neuron number
- decreased neuron number
- decreased sensory neuron number
- decreased spinal cord size
- decreased survivor rate
- dilated heart atrium
- dilated heart right ventricle
- dilated pulmonary artery
- enlarged heart
- female infertility
- heart right ventricle outflow tract stenosis
- hunched posture
- hypoactivity
- impaired limb coordination
- increased heart right ventricle size
- limb grasping
- muscular atrophy
- neonatal lethality incomplete penetrance
- no abnormal phenotype detected
- ostium secundum atrial septal defect
- overriding aortic valve
- perimembraneous ventricular septal defect
- perinatal lethality incomplete penetrance
- persistent truncus arteriosis
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature closure of the ductus arteriosus
- pulmonary alveolar hemorrhage
- pulmonary edema
- pulmonary valve stenosis
- sinus venosus hypoplasia
- small L4 dorsal root ganglion
- small L5 dorsal root ganglion
- small cochlear ganglion
- small dorsal root ganglion
- small geniculate ganglion
- small mesencephalic trigeminal nucleus
- small nodose ganglion
- small petrosal ganglion
- small superior cervical ganglion
- small trigeminal ganglion
- thick aortic valve cusps
- thick mitral valve cusps
- thick pulmonary valve cusps
- vascular smooth muscle hypotrophy
role in cell
- cell death
- cell viability
- apoptosis
- morphology
- proliferation
- activation in
- molecular cleavage in
- chemoattraction
- density
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- postsynaptic region
- vesicles
- endoplasmic reticulum lumen
- perinuclear space
- cytoplasmic vesicles
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive chemotaxis
- signal transduction
- positive regulation of receptor internalization
- positive regulation of cell proliferation
- neuron projection morphogenesis
- cell-cell signaling
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- negative regulation of neuron apoptotic process
- nerve development
- regulation of synaptic transmission
- activation of protein kinase B activity
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of peptidyl-serine phosphorylation
- induction of positive chemotaxis
- positive regulation of cell migration
- negative regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding
- chemoattractant activity
- receptor binding