Lamb3 Gene Summary [Mouse]
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within brown fat cell differentiation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lamb3 |
| Official Name | laminin, beta 3 [Source:MGI Symbol;Acc:MGI:99915] |
| Ensembl ID | ENSMUSG00000026639 |
| Bio databases IDs | |
| Aliases | laminin, beta 3 |
| Synonyms | AI1A, BM600-125KDA, JEB1A, JEB1B, Kalinin B1, LAM5, laminin, beta 3, laminin subunit beta 3, laminin subunit β 3, Laminin subunit β 3 precursor, Laminin β 3, laminin, β 3, LAMNB1, LOC305078 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin domain VI
- SPEC
- Laminin N-terminal (Domain VI)
- laminin domain V
- Laminin domain IIIa
- PspA/IM30 family
- protein binding
- EGF_CA
- Laminin Domain I
- Laminin-type epidermal growth factor-like domai
- binding protein
- Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
- Methyl-accepting chemotaxis protein (MCP), signaling domain
- C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family
- Apolipoprotein A1/A4/E domain
- transporter
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lamb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- epithelial cancer
- revertant mosaicism of non-Herlitz junctional epidermolysis bullosa type 1A
- epidermolysis bullosa letalis
- neoplasia
- metastasis
- junctional epidermolysis bullosa
- epileptic seizure
- amelogenesis imperfecta type IA
role in cell
- proliferation
- migration
- cell viability
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
- basal lamina
- interphotoreceptor matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- epidermis development
- endodermal cell differentiation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- laminin-5 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- extracellular matrix structural constituent