Ntf3 Gene Summary [Rat]
Enables nerve growth factor binding activity. Involved in several processes, including myelination; positive regulation of glial cell differentiation; and response to immobilization stress. Predicted to be located in cytoplasmic vesicle. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Biomarker of alcohol use disorder; borna disease; and status epilepticus. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntf3 |
| Official Name | neurotrophin 3 [Source:RGD Symbol;Acc:619728] |
| Ensembl ID | ENSRNOG00000019716 |
| Bio databases IDs | |
| Aliases | neurotrophin 3 |
| Synonyms | AI316846, AI835689, HDNF, neurotrophin 3, NGF-2, NT-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ntf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotrophin p75 receptor binding
- Neutrophin-3 N-terminus
- chemoattractant
- protein binding
- receptor binding
- growth factor
- growth factor binding
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Ntf3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- neurodegeneration
- Alzheimer disease
- motor dysfunction or movement disorder
- persistent truncus arteriosus
- ataxia
- heat hyperalgesia
- systemic lupus erythematosus
- insomnia
- neurological signs
role in cell
- cell death
- cell viability
- apoptosis
- morphology
- proliferation
- activation in
- molecular cleavage in
- chemoattraction
- density
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- postsynaptic region
- vesicles
- endoplasmic reticulum lumen
- perinuclear space
- cytoplasmic vesicles
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ntf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive chemotaxis
- signal transduction
- positive regulation of receptor internalization
- positive regulation of cell proliferation
- neuron projection morphogenesis
- cell-cell signaling
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- negative regulation of neuron apoptotic process
- nerve development
- regulation of synaptic transmission
- activation of protein kinase B activity
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of peptidyl-serine phosphorylation
- induction of positive chemotaxis
- positive regulation of cell migration
- negative regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding
- chemoattractant activity
- receptor binding