NTF3
NTF3 Gene Summary
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NTF3 |
| Official Name | neurotrophin 3 [Source:HGNC Symbol;Acc:HGNC:8023] |
| Ensembl ID | ENSG00000185652 |
| Bio databases IDs | |
| Aliases | neurotrophin 3 |
| Synonyms | AI316846,AI835689,HDNF,neurotrophin 3,NGF-2,NT-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotrophin p75 receptor binding
- Neutrophin-3 N-terminus
- chemoattractant
- protein binding
- receptor binding
- growth factor
- growth factor binding
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the NTF3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NGF
- BDNF
- NTF4
- NTRK3
- LAMB3
- NGFR
- MEOX2
- NTRK1
- LRP1
- NTRK2
disease
- Parkinson disease
- neurodegeneration
- Alzheimer disease
- motor dysfunction or movement disorder
- persistent truncus arteriosus
- ataxia
- heat hyperalgesia
- systemic lupus erythematosus
- insomnia
- neurological signs
regulated by
- potassium chloride
- insulin
- guanidine
- NGFR
- dexamethasone
- quinolinic acid
- APP
- lipopolysaccharide
- paclitaxel
- LH
regulates
- CASP3
- CASP9
- FOS
- CASP8
- NGFR
- DNA promoter
- DNA endogenous promoter
- p38 MAPK
- ERK
- AKT
role in cell
- cell death
- cell viability
- apoptosis
- morphology
- proliferation
- activation in
- molecular cleavage in
- chemoattraction
- density
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- postsynaptic region
- vesicles
- endoplasmic reticulum lumen
- perinuclear space
- cytoplasmic vesicles
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NTF3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive chemotaxis
- signal transduction
- positive regulation of receptor internalization
- positive regulation of cell proliferation
- neuron projection morphogenesis
- cell-cell signaling
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- negative regulation of neuron apoptotic process
- nerve development
- regulation of synaptic transmission
- activation of protein kinase B activity
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of peptidyl-serine phosphorylation
- induction of positive chemotaxis
- positive regulation of cell migration
- negative regulation of peptidyl-tyrosine phosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- extracellular region
- axon
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding
- chemoattractant activity
- receptor binding