CHST10 Gene Summary

This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

Details

Type
Protein Coding
Official Symbol
CHST10
Official Name
carbohydrate sulfotransferase 10 [Source:HGNC Symbol;Acc:HGNC:19650]
Ensembl ID
ENSG00000115526
Bio databases IDs NCBI: 9486 Ensembl: ENSG00000115526
Aliases carbohydrate sulfotransferase 10
Synonyms
carbohydrate sulfotransferase 10,carbohydrate sulphotransferase 10,HNK-1ST,raHNK-1ST,ST,sul-T
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sulfotransferase
  • catalytic domain
  • enzyme
  • Sulfotransferase family
  • HNK-1 sulfotransferase

Pathways

Biological processes and signaling networks where the CHST10 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Alzheimer disease
  • hyperplasia
regulates
  • estrogen
  • IgG
  • DAG1
  • dehydroisoandrosterone
  • beta-estradiol
  • androgen
  • NCAM1
  • 5beta-androstane-3alpha,17-alpha-diol-11-one-17-beta-carboxylic acid glucuronide
  • HNK-1 carbohydrate
  • testosterone
role in cell
  • expression in
  • adhesion
  • invasiveness
  • migration
  • excitatory postsynaptic potential
  • long-term potentiation
  • glycosylation in
  • formation in
  • sulfation in
  • transmission

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • Golgi Apparatus
  • Golgi membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CHST10 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • long-term memory
  • androgen metabolic process
  • estrogen metabolic process
  • carbohydrate biosynthetic process
  • cell adhesion
  • proteoglycan biosynthetic process
  • learning

cellular COMPONENT

Where in the cell the gene product is active
  • membrane
  • Golgi membrane
  • Golgi apparatus

molecular FUNCTION

What the gene product does at the molecular level
  • HNK-1 sulfotransferase activity
  • sulfotransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.