B3GAT2 Gene Summary [Human]
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | B3GAT2 |
| Official Name | beta-1,3-glucuronyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:922] |
| Ensembl ID | ENSG00000112309 |
| Bio databases IDs | |
| Aliases | beta-1,3-glucuronyltransferase 2, glucuronosyltransferase S, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 |
| Synonyms | AF106624, beta-1,3-glucuronyltransferase 2, GLCATS, Udp Glucuronyltransferase S, β-1,3-glucuronyltransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human B3GAT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 43
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- catalytic domain
- enzyme
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human B3GAT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- chondroitin sulfate proteoglycan biosynthetic process
- carbohydrate biosynthetic process
- protein glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity