RELB Gene Summary [Human]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RELB |
| Official Name | RELB proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9956] |
| Ensembl ID | ENSG00000104856 |
| Bio databases IDs | |
| Aliases | RELB proto-oncogene, NF-kB subunit |
| Synonyms | avian reticuloendotheliosis viral (v-rel) oncogene related B, IMD53, I-REL, RELB proto-oncogene, NF-kB subunit, shep |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RELB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RelB transactivation domain
- transcription regulator
- protein kinase binding
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- RelB leucine zipper
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the RELB gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Angiopoietin Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- BMP signaling pathway
- GADD45 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-9 Signaling
- Induction of Apoptosis by HIV1
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- NF-κB Signaling
- PEDF Signaling
- Rac Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- neoplasia
- alopecia
- androgenic alopecia
- sepsis
- delayed hypersensitive reaction
- dermatitis
- Alzheimer disease
- hyperkeratosis
role in cell
- expression in
- transactivation in
- cell death
- differentiation
- activation in
- production in
- binding
- quantity
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular space
- centrosome
- cytosol
- nucleoplasm
- synapse
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RELB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- NIK/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- I-kappaB kinase/NF-kappaB cascade
- T-helper 1 cell differentiation
- circadian regulation of gene expression
- inflammatory response
- cellular response to osmotic stress
- negative regulation of transcription, DNA-dependent
- myeloid dendritic cell differentiation
- innate immune response
- lymphocyte differentiation
- cellular response to stress
- antigen processing and presentation
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- transcriptional repressor complex
- cytosol
- macromolecular complex
- NF-kappaB complex
- synapse
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity