H1-4 Gene Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | H1-4 |
| Official Name | H1.4 linker histone, cluster member [Source:HGNC Symbol;Acc:HGNC:4718] |
| Ensembl ID | ENSG00000168298 |
| Bio databases IDs | |
| Aliases | H1.4 linker histone, cluster member |
| Synonyms | dJ221C16.5,H1.4,H1.4 linker histone, cluster member,H1d,H1E,H1F4,H1s-4,H1var2,H1 VAR.2,Hist1h1c,Hist1h1d,HIST1H1E,Histone H1.2,RMNS |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- H15
- ADP binding
- ATP binding
- calcium ion binding
- central domain
- histone deacetylase binding
- chromatin binding
- protein binding
- purine nucleotide binding
- DNA binding
- structural constituent of chromatin
- GTP binding
- linker histone H1 and H5 family
- AMP binding
- binding protein
- double-stranded DNA binding
- adenyl nucleotide binding
Pathways
Biological processes and signaling networks where the H1-4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chorioallantoic membrane fusion failure
- auditory neuropathy
- Rahman syndrome
- plasma cell myeloma
- hereditary disorder
- neurodevelopmental disorder
- growth failure
- syndromic mental retardation
- latent tuberculosis
role in cell
- expression in
- organization
- compaction
- condensation
- delivery in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- nucleosomes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the H1-4 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromosome condensation
- nucleosome assembly
- negative regulation of DNA recombination
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- heterochromatin
- euchromatin
- nucleosome
molecular FUNCTION
What the gene product does at the molecular level
- chromatin DNA binding
- structural constituent of chromatin
- protein binding
- RNA binding
- histone deacetylase binding
- nucleosomal DNA binding
- double-stranded DNA binding