Slc20a2 Gene Summary [Mouse]
Enables sodium:phosphate symporter activity. Involved in positive regulation of bone mineralization. Predicted to be located in apical plasma membrane and brush border membrane. Is expressed in several structures, including alimentary system; liver; male reproductive gland or organ; spleen; and yolk sac. Used to study basal ganglia calcification. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc20a2 |
| Official Name | solute carrier family 20, member 2 [Source:MGI Symbol;Acc:MGI:97851] |
| Ensembl ID | ENSMUSG00000037656 |
| Bio databases IDs | |
| Aliases | solute carrier family 20, member 2 |
| Synonyms | Ab1-188, GLVR-2, IBGC1, IBGC2, IBGC3, LOC100507493, LOC100508150, MLVAR, MolPit2, PIT-2, RAM-1, solute carrier family 20 member 2, solute carrier family 20, member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc20a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- viral receptor
- sodium:phosphate symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic basal ganglia calcification type 1
- hereditary disorder
- acute myeloid leukemia
- familial idiopathic basal ganglia calcification
- gout
- tonsillitis
phenotypes
- abnormal auditory brainstem response
- abnormal bone structure
- abnormal incisor color
- abnormal iris morphology
- abnormal lens morphology
- abnormal motor coordination/ balance
- abnormal spine curvature
- abnormal vocalization
- absent pinna reflex
- cataract
- decreased body length
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating insulin level
- decreased fasting circulating glucose level
- decreased total body fat amount
- developmental and structural abnormality
- developmental dysplasia
- eyelids fail to open
- impaired glucose tolerance
- increased circulating alkaline phosphatase level
- increased circulating magnesium level
- increased grip strength
- increased lean body mass
- irregularly shaped pupil
- kyphosis
- mineralisation
- narrow eye opening
- preweaning lethality incomplete penetrance
- abnormal atrioventricular cushion morphology
- abnormal basal ganglion morphology
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal cerebral cortex morphology
- abnormal circulating alkaline phosphatase level
- abnormal forebrain morphology
- abnormal hypoglossal nerve topology
- abnormal liver vasculature morphology
- abnormal mineral level
- abnormal thalamus morphology
- abnormal vena cava morphology
- anomalous pulmonary venous connection
- arteriovenous malformation
- calcified brain
- decreased circulating phosphate level
- ectopic cartilage
- embryo cyst
- embryo tumor
- fusion of vertebral arches
- hemangioma
- microgliosis
- multiple persisting craniopharyngeal ducts
- small superior cervical ganglion
- subcutaneous edema
role in cell
- mineralization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc20a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- ion transport
- sodium ion transmembrane transport
- positive regulation of bone mineralization
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- extracellular vesicular exosome
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- sodium:phosphate symporter activity
- signaling receptor activity
- viral receptor activity