Fgf23 Gene Summary [Mouse]
This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | Fgf23 |
| Official Name | fibroblast growth factor 23 [Source:MGI Symbol;Acc:MGI:1891427] |
| Ensembl ID | ENSMUSG00000000182 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 23 |
| Synonyms | ADHR, Fgf8b, FGFN, fibroblast growth factor 23, HFTC2, HPDR2, HYPF, PHPTC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 1 fibroblast growth factor receptor binding
- protein binding
- fibroblast growth factor receptor binding
- growth factor
- RXXR motif
Pathways
Biological processes and signaling networks where the Fgf23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoglycemia
- primary hyperthyroidism
- hypercalcemia
- chronic kidney disease
- atherosclerosis
- autosomal dominant hypophosphatemic rickets
- X-linked hypophosphatemic rickets
- sickle cell anemia
- phosphaturic mesenchymal tumor
- mineralizing enthesopathy
role in cell
- motility
- expression in
- phosphorylation in
- activation in
- apoptosis
- proliferation
- number
- differentiation
- frequency
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- positive regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- negative regulation of osteoblast differentiation
- negative regulation of bone mineralization
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- cellular response to interleukin-6
- positive regulation of transcription, DNA-dependent
- cellular response to parathyroid hormone stimulus
- cellular response to leptin stimulus
- response to magnesium ion
- cellular phosphate ion homeostasis
- phosphate ion homeostasis
- positive regulation of MAPK cascade
- negative regulation of hormone secretion
- vitamin D catabolic process
- organ morphogenesis
- ERK1 and ERK2 cascade
- regulation of phosphate transport
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
- positive regulation of vitamin D 24-hydroxylase activity
- cellular response to vitamin D
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- cytoplasm
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- type 1 fibroblast growth factor receptor binding