Lair1 Gene Summary [Mouse]
Predicted to be involved in immune response-regulating signaling pathway. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lair1 |
| Official Name | leukocyte-associated Ig-like receptor 1 [Source:MGI Symbol;Acc:MGI:105492] |
| Ensembl ID | ENSMUSG00000055541 |
| Bio databases IDs | |
| Aliases | leukocyte-associated Ig-like receptor 1 |
| Synonyms | 5133400O11Rik, D7Bwg0421e, leukocyte-associated Ig-like receptor 1, leukocyte-associated immunoglobulin-like receptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lair1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- transmembrane domain
- intracellular domain
Pathways
Biological processes and signaling networks where the Lair1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- collagen-induced arthritis
- thrombocytosis
phenotypes
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgG1 level
- decreased thymocyte number
- increased B cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD8-positive alpha-beta memory T cell number
- increased activated T cell number
- increased dendritic cell number
- increased eosinophil cell number
- increased marginal zone B cell number
- no abnormal phenotype detected
- thrombocytosis
role in cell
- phosphorylation in
- number
- production in
- G1 phase
- degranulation
- cytotoxic reaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface