SIRT5 Gene Summary [Human]
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | SIRT5 |
| Official Name | sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933] |
| Ensembl ID | ENSG00000124523 |
| Bio databases IDs | |
| Aliases | sirtuin 5 |
| Synonyms | 0610012J09RIK, 1500032M05RIK, LOC285813, SIR2L5, sirtuin 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NAD or NADH binding
- binding protein
- zinc ion binding
- linear amide carbon-nitrogen bond hydrolase
- enzyme
- protein binding
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the SIRT5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- myocardial necrosis
- prostate cancer
- tumorigenesis
- organismal death
- hypertrophic cardiomyopathy
- hepatocellular carcinoma
- mitochondrial disorder
role in cell
- growth
- apoptosis
- phosphorylation in
- expression in
- production in
- proliferation
- migration
- degradation in
- invasion by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial inner membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein demalonylation
- peptidyl-lysine demalonylation
- protein desuccinylation
- regulation of ketone biosynthetic process
- protein deacetylation
- negative regulation of cardiac muscle cell apoptotic process
- peptidyl-lysine desuccinylation
- response to nutrient levels
- regulation of gene expression, epigenetic
- mitochondrion organization
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- NAD-dependent protein deacetylase activity
- protein-malonyllysine demalonylase activity
- protein-succinyllysine desuccinylase activity
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity