AURKB Gene Summary [Human]
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | AURKB |
| Official Name | aurora kinase B [Source:HGNC Symbol;Acc:HGNC:11390] |
| Ensembl ID | ENSG00000178999 |
| Bio databases IDs | |
| Aliases | aurora kinase B, aurora-B, aurora-1, protein phosphatase 1, regulatory subunit 48 |
| Synonyms | AIK2, AIM-1, AIRK2, ARK-2, AurB, aurkb-sv1, aurkb-sv2, AURORA B, aurora kinase B, IPL1, PPP1R48, Serine/threonine kinase 5, STK-1, STK12, STK5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AURKB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase binding
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the AURKB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- neoplasia
- papillomatosis
- oral cancer
- small cell lung carcinoma
- melanoma
- melanoma cancer
role in cell
- differentiation
- proliferation
- binding in
- quantity
- survival
- apoptosis
- cell viability
- expression in
- cell death
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- anaphase bridge
- microtubule cytoskeleton
- mid-section
- heterochromatin
- cell center
- spindle apparatus
- Cytoplasm
- centrosome
- contractile rings
- midbody remnant
- midbody
- metaphase plate
- cytosol
- centromeric region
- nuclear foci
- chromosome
- nucleoplasm
- spindle pole
- nuclear scaffolds
- polar microtubule
- cleavage furrow
- central spindle
- kinetochores
- centromeres
- chromatin
- pericentric heterochromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AURKB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- mitotic spindle organization
- protein autophosphorylation
- protein phosphorylation
- post-translational protein modification
- negative regulation of innate immune response
- negative regulation of protein binding
- mitotic cell cycle
- negative regulation of transcription from RNA polymerase II promoter
- regulation of chromosome segregation
- cytokinesis after mitosis
- protein localization to kinetochore
- regulation of cytokinesis
- cellular response to UV
- negative regulation of cytokinesis
- positive regulation of cytokinesis
- cleavage furrow formation
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- abscission
- positive regulation of telomerase activity
- spindle midzone assembly involved in mitosis
- attachment of spindle microtubules to kinetochore
- negative regulation of B cell apoptotic process
- positive regulation of telomere maintenance via telomerase
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- condensed chromosome, centromeric region
- kinetochore
- nucleoplasm
- spindle pole centrosome
- nucleus
- spindle microtubule
- spindle midzone
- chromocenter
- spindle
- cytosol
- chromosome passenger complex
- midbody
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein serine/threonine kinase activity
- kinase binding