GLYR1 Gene Summary [Human]
Enables DNA binding activity; methylated histone binding activity; and nucleosome binding activity. Involved in positive regulation of histone acetylation and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GLYR1 |
| Official Name | glyoxylate reductase 1 homolog [Source:HGNC Symbol;Acc:HGNC:24434] |
| Ensembl ID | ENSG00000140632 |
| Bio databases IDs | |
| Aliases | glyoxylate reductase 1 homolog, nuclear protein 60kDa |
| Synonyms | 2810419J22RIK, 3930401K13Rik, BM045, glyoxylate reductase 1 homolog, glyoxylate reductase 1 homolog (Arabidopsis), HIBDL, hNDF, NDF, NP60, N-PAC, RGD1309459 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLYR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
- histone binding
- 2-hydroxy-3-oxopropionate reductase
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- chromatin binding
- protein binding
- DNA binding
- binding protein
- NAD binding domain of 6-phosphogluconate dehydrogenase
- NADP oxidoreductase coenzyme F420-dependent
- garR
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLYR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- NADP binding
- protein binding
- histone binding
- NAD binding
- nucleosome binding
- methylated histone residue binding
- chromatin binding