PRSS23 Gene Summary [Human]
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | PRSS23 |
| Official Name | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] |
| Ensembl ID | ENSG00000150687 |
| Bio databases IDs | |
| Aliases | serine protease 23 |
| Synonyms | 1700019G06RIK, 2310046G15Rik, 4930479H08Rik, LOC102724764, PROTEASE SERINE 23, SERINE PROTEASE, serine protease 23, SIG13, SPUVE, ZSIG13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRSS23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- Trypsin-like peptidase domain
- protein binding
Pathways
Biological processes and signaling networks where the PRSS23 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- epithelial cancer
- aortic valve calcification
- organismal death
- gastric cancer
- autosomal dominant polycystic kidney disease
- papillary thyroid cancer
- liver cancer
- systemic sclerosis
role in cell
- expression in
- growth
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRSS23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- endoplasmic reticulum lumen
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity