MAPK8IP2 Gene Summary [Human]
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Details
| Type | Protein Coding |
| Official Symbol | MAPK8IP2 |
| Official Name | mitogen-activated protein kinase 8 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6883] |
| Ensembl ID | ENSG00000008735 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 8 interacting protein 2, islet-brain 2, JNK-interacting protein 2 |
| Synonyms | 3230402N03Rik, AW049958, IB-2, JIP-2, LOC284939, mitogen-activated protein kinase 8 interacting protein 2, PRKM8IPL, R75148 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAPK8IP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- kinesin1 binding domain
- binding protein
- protein kinase binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- structural molecule
- kinesin binding
- FHF-binding domain
- MAP-kinase scaffold protein
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the MAPK8IP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- morbid obesity
- ataxia
- hypoglycemia
- androgenic alopecia
- growth failure
- infection by Dengue virus 2
role in cell
- abnormal morphology
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- peripheral membrane fraction
- cell surface
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAPK8IP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- signal complex assembly
- regulation of excitatory postsynaptic membrane potential
- nonassociative learning
- JNK cascade
- regulation of JNK cascade
- dendrite morphogenesis
- behavioral fear response
- mating behavior
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- regulation of receptor activity
- regulation of synaptic transmission, glutamatergic
- positive regulation of stress-activated MAPK cascade
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- macromolecular complex
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- structural molecule activity
- kinesin binding
- JUN kinase binding
- MAP-kinase scaffold activity
- beta-amyloid binding