Gsta1 Gene Summary [Mouse]
Enables glutathione transferase activity. Involved in response to stilbenoid. Acts upstream of or within response to bacterium and response to caloric restriction. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; heart; skeleton; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA5 (glutathione S-transferase alpha 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsta1 |
| Official Name | glutathione S-transferase, alpha 1 (Ya) [Source:MGI Symbol;Acc:MGI:1095417] |
| Ensembl ID | ENSMUSG00000074183 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, alpha 1 (Ya) |
| Synonyms | glutathione S-transferase alpha 13, glutathione S-transferase, alpha 1 (Ya), glutathione S-transferase, alpha 2 (Yc2), glutathione S-transferase alpha 5, glutathione S-transferase α 13, glutathione S-transferase, α 1 (Ya), glutathione S-transferase, α 2 (Yc2), glutathione S-transferase α 5, Gm10639, Gm3776, Gst1-1, Gst2-1, Gst2-2, Gsta1-1, Gsta13, Gsta2, Gsta5, Gstc-2, Gstya, Gst-ya2, Gst Yc, Gst yc2, LOC100048652, MGC29061, Timd5 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- glutathione transferase
- fatty acid binding
- steroid D-isomerase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein homodimerization
- enzyme
- glutathione peroxidase
Pathways
Biological processes and signaling networks where the Gsta1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alloxan-induced diabetic nephropathy
- diabetic nephropathy
regulates
- glutathione
- cumene hydroperoxide
- p-nitrophenyl acetate
- 1-chloro-2,4-dinitrobenzene
- trans-4-phenylbut-3-en-2-one
- 5-androstene-3,17-dione
- ethacrynic acid
- 4-nitrobenzyl chloride
- xenobiotic
- Gsta1 (includes others)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol