Gsta3 Gene Summary [Mouse]
Enables glutathione transferase activity. Involved in ureteric bud development. Acts upstream of or within aflatoxin catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsta3 |
| Official Name | glutathione S-transferase, alpha 3 [Source:MGI Symbol;Acc:MGI:95856] |
| Ensembl ID | ENSMUSG00000025934 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, alpha 3 |
| Synonyms | glutathione S-transferase alpha 3, glutathione S-transferase, alpha 3, glutathione S-transferase α 3, glutathione S-transferase, α 3, Gst2-3, Gst3a, Gsta5, Gst-yc2, Gst-yl, Yc2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsta3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
Pathways
Biological processes and signaling networks where the Gsta3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- streptozotocin-induced diabetic nephropathy
regulates
- glutathione
- aflatoxin B1-2,3-oxide
- cumene hydroperoxide
- 5-androstene-3,17-dione
- trans-4-phenylbut-3-en-2-one
- 1-chloro-2,4-dinitrobenzene
- ethacrynic acid
- 4-hydroxynonenal
- p-nitrophenyl acetate
- 1,2-epoxy-3-(p-nitrophenoxy)propane
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol