USP33 Gene Summary [Human]
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | USP33 |
| Official Name | ubiquitin specific peptidase 33 [Source:HGNC Symbol;Acc:HGNC:20059] |
| Ensembl ID | ENSG00000077254 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 33 |
| Synonyms | 9830169D19RIK, ubiquitin specific peptidase 33, VDU1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- peptidase
- G-protein-coupled receptor binding
- enzyme binding
- DUSP domain
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
- cysteine endopeptidase
- Zn-finger in ubiquitin-hydrolases and other protein
- zinc ion binding
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
Pathways
Biological processes and signaling networks where the USP33 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- ovarian cancer
- pancreatic cancer
role in cell
- degradation in
- proliferation
- apoptosis
- expression in
- invasion by
- migration
- ubiquitination in
- amplification
- sphere formation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- focal adhesions
- centrosome
- Golgi Apparatus
- cytosol
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- positive regulation of protein binding
- axon guidance
- cellular response to starvation
- regulation of G-protein coupled receptor protein signaling pathway
- endocytosis
- negative regulation of protein binding
- ubiquitin-dependent protein catabolic process
- centrosome duplication
- regulation of autophagy
- protein stabilization
- cell migration
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- VCB complex
- cytosol
- Golgi apparatus
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- G-protein coupled receptor binding
- zinc ion binding
- protein binding
- ubiquitin binding
- cysteine-type endopeptidase activity
- small GTPase binding