ZFR Gene Summary [Human]
This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | ZFR |
| Official Name | zinc finger RNA binding protein [Source:HGNC Symbol;Acc:HGNC:17277] |
| Ensembl ID | ENSG00000056097 |
| Bio databases IDs | |
| Aliases | zinc finger RNA binding protein |
| Synonyms | C920030H05RIK, SPG71, ZFR1, Zinc finger-binding, Zinc finger RNA-binding, zinc finger RNA binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DZF domain
- Zinc-finger double-stranded RNA-binding
- U1 zinc finger
- protein binding
- Zinc-finger of C2H2 type
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
role in cell
- apoptosis
- phosphorylation in
- mitosis
- oxidative phosphorylation in
- alternative splicing in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule clusters
- pronucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFR gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- RNA binding
- protein binding
- double-stranded RNA binding
- single-stranded RNA binding