SAMM50 Gene Summary [Human]
This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | SAMM50 |
| Official Name | SAMM50 sorting and assembly machinery component [Source:HGNC Symbol;Acc:HGNC:24276] |
| Ensembl ID | ENSG00000100347 |
| Bio databases IDs | |
| Aliases | SAMM50 sorting and assembly machinery component |
| Synonyms | 1110030L07Rik, CGI-51, OMP85, SAM50, SAMM50 sorting and assembly machinery component, TOB55, TRG-3, YNL026W |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SAMM50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Omp85 superfamily domain
- Surface antigen variable number repeat
- protein binding
Pathways
Biological processes and signaling networks where the SAMM50 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- infection by HIV-1
role in cell
- expression in
- formation
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SAMM50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial outer membrane
- cristae formation
- mitochondrial respiratory chain complex assembly
- inner mitochondrial membrane organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrion
- membrane
- mitochondrial outer membrane
- mitochondrial sorting and assembly machinery complex
Molecular Function
What the gene product does at the molecular level
- protein binding