Cadm3 Gene Summary [Mouse]
Enables protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within protein localization. Located in cell-cell junction. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cadm3 |
| Official Name | cell adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:2137858] |
| Ensembl ID | ENSMUSG00000005338 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 3 |
| Synonyms | BIgR, cell adhesion molecule 3, CMT2FF, IGSF4B, NECL1, SynCAM3, TSLL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cadm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- putative band 4.1 homologues' binding motif
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- protein homodimerization
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- schizophrenia
- colorectal cancer
- endometriosis
- Charcot-Marie-Tooth disease axonal type 2FF
- diabetic nephropathy
- pervasive developmental disorder
- acute graft-vs-host disease
role in cell
- adhesion
- accumulation in
- cell-cell adhesion
- clustering in
- diffusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- intercellular junctions
- presynaptic membrane
- internodes
- synapse
- Schmidt-Lanterman incisures
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cadm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterophilic cell-cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cell-cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding