Kcna2 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Part of voltage-gated potassium channel complex. Is active in axon initial segment. Is expressed in several structures, including brain; heart ventricle; and hindlimb muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna2 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, member 2 [Source:MGI Symbol;Acc:MGI:96659] |
| Ensembl ID | ENSMUSG00000040724 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, member 2 |
| Synonyms | Akr6a4, BK2, DEE32, EIEE32, Gm10672, HBK5, HK4, HUKIV, Kca1-2, KV1.2, KV1.2 alpha, KV1.2 α, MK2, NGK1, potassium voltage-gated channel, shaker-related subfamily, member 2, potassium voltage-gated channel subfamily A member 2, Rak, RBK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- delayed rectifier potassium channel
- cortactin binding span
- Ion transport protein
- BTB_POZ
- protein binding
- ion channel
- kinesin binding
- voltage-gated potassium channel
- subregion I of the P region
- Broad-Complex, Tramtrack and Bric a brac
- cytosolic tail domain
- voltage-gated ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- hereditary disorder
- early infantile epileptic encephalopathy type 32
- multiple sclerosis
- nonarteritic ischemic optic neuropathy
- Ohtahara syndrome
- X-linked myoclonic epilepsy with generalized spasticity and intellectual disability
- epileptic encephalopathy
- neurodevelopmental disorder
- secondary progressive multiple sclerosis
role in cell
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- axon component
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- nodes of Ranvier
- axonal membrane
- paranodes
- paranodal junctions
- nerve ending
- axon initial segments
- juxtaparanodes
- synaptosomes
- membrane processes
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- axon terminals
- lamellipodia
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcna2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- regulation of postsynaptic membrane potential
- potassium ion transmembrane transport
- protein homooligomerization
- optic nerve structural organization
- cerebral cortex development
- corpus callosum development
- potassium ion transport
- regulation of circadian sleep/wake cycle, non-REM sleep
- sensory perception of pain
- regulation of action potential
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- paranodal junction
- voltage-gated potassium channel complex
- neuronal cell body membrane
- juxtaparanode region of axon
- perikaryon
- axon terminus
- plasma membrane
- calyx of Held
- endoplasmic reticulum membrane
- dendrite
- initial segment
- postsynaptic membrane
- membrane
- axon
- lamellipodium membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- delayed rectifier potassium channel activity
- kinesin binding
- outward rectifier potassium channel activity
- potassium channel activity