Dao Gene Summary [Mouse]
Enables D-amino-acid dehydrogenase activity; D-amino-acid oxidase activity; and FAD binding activity. Involved in several processes, including D-alanine catabolic process; dopamine biosynthetic process; and neutrophil-mediated killing of gram-negative bacterium. Acts upstream of or within L-leucine metabolic process. Located in extracellular space and peroxisomal matrix. Is expressed in metanephros; renal cortex; ureter; and urinary system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dao |
| Official Name | D-amino acid oxidase [Source:MGI Symbol;Acc:MGI:94859] |
| Ensembl ID | ENSMUSG00000042096 |
| Bio databases IDs | |
| Aliases | D-amino acid oxidase |
| Synonyms | AI987963, DAAO, D-Amino Acid Oxidase, DAMOX, DAO1, DEAMINOACID OXIDASE, OXDA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dao often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- D-amino-acid oxidase
- FAD dependent oxidoreductase
- enzyme
- protein binding
- identical protein binding
- D-amino-acid dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- pain
- amyotrophic lateral sclerosis
- bipolar disorder
- opioid dependence
regulates
- dopamine
- L-serine
- leucine
- D-alanine
- L-proline
- D-serine
- DAO
- D-amino acid
- heparin
- heparan sulfate
role in cell
- migration
- growth
- apoptosis
- long-term potentiation
- quantity
- size
- damage
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Extracellular Space
- microbody
- cytosol
- mitochondrial outer membrane
- synapse
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dao gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine biosynthetic process
- D-alanine catabolic process
- D-serine metabolic process
- D-serine catabolic process
- digestion
- D-amino acid catabolic process
- proline catabolic process
- neutrophil mediated killing of gram-negative bacterium
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- cytoplasm
- cytosol
- peroxisomal matrix
- mitochondrial outer membrane
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- FAD binding
- identical protein binding
- protein binding
- D-amino-acid oxidase activity