Cd5l Gene Summary [Mouse]
Acts upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface and plasma membrane. Is expressed in several structures, including central nervous system; immune system; liver; retina; and testis. Orthologous to human CD5L (CD5 molecule like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd5l |
| Official Name | CD5 antigen-like [Source:MGI Symbol;Acc:MGI:1334419] |
| Ensembl ID | ENSMUSG00000015854 |
| Bio databases IDs | |
| Aliases | CD5 antigen-like |
| Synonyms | 1/6, AAC-11, AIM, API6, Apoptosis inhibitor 6, CD5 antigen-like, CD5 molecule like, CT-2, hAIM, mAIM, Pdp, PRO229, SP-ALPHA, SP-α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd5l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- ectodomain
- transmembrane receptor
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- diabetic nephropathy
- insulin resistance
- acute kidney injury
- hepatitis B virus-related hepatocellular carcinoma
- acute lung injury
- impaired glucose tolerance
- infection by bacteria
role in cell
- apoptosis
- number
- quantity
- maturation
- phagocytosis
- recruitment
- response
- phagocytosis by
- abnormal morphology
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd5l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- zymogen activation
- inflammatory response
- regulation of complement activation
- apoptotic process
- immune system process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- blood microparticle
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity