Cxcl1 Gene Summary [Mouse]
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl1 |
| Official Name | chemokine (C-X-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:108068] |
| Ensembl ID | ENSMUSG00000029380 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 1 |
| Synonyms | CINC-1, C-X-C motif chemokine ligand 1, Fsp, Gro, Gro1, Gro alpha, Gro α, KC, KC-GRO, Keratinocyte-derived chemokine, Keratinocyte-derived cytokine, Mgsa, N51, Scyb1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
Pathways
Biological processes and signaling networks where the Cxcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Granulocyte Adhesion and Diapedesis
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-8 Signaling
- Lymphotoxin β Receptor Signaling
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- metastasis
- pulmonary fibrosis
- experimentally-induced arthritis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- hypernociception
- atherosclerosis
- Marfan syndrome
role in cell
- activation
- production in
- cellular infiltration by
- proliferation
- number
- expression in
- recruitment
- frequency
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- perinuclear region
- exosomes
- plasma