H2-Aa Gene Summary [Mouse]
Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | H2-Aa |
| Official Name | histocompatibility 2, class II antigen A, alpha [Source:MGI Symbol;Acc:MGI:95895] |
| Ensembl ID | ENSMUSG00000036594 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, class II antigen A, alpha |
| Synonyms | Aalpha, alpha subunit of DS GLYCOPROTEIN, CELIAC1, DQ-A1, ds glycoprotein α subunit, H2-Aa, H2-Aa1, histocompatibility 2, class II antigen A, alpha, histocompatibility 2, class II antigen A, α, HLA-DQA, HLA-DQ alpha3, HLA-DQB1, Ia-1, I-Aalpha, I-A MHC II Alpha 1, I-A MHC II α 1, LOC100294114, LOC100294162, LOC100294190, LOC100294224, LOC100294277, LOC100294317, LOC100507718, LOC731682, major histocompatibility complex, class II, DQ alpha 1, major histocompatibility complex, class II, DQ α 1, α subunit of DS GLYCOPROTEIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Aa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- MHC class II receptor
- binding protein
- antigen binding domain
- immunoglobulin domain
- Class II histocompatibility antigen, alpha domain
- protein binding
- transmembrane receptor
- peptide antigen binding
Pathways
Biological processes and signaling networks where the H2-Aa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sinusitis
- rheumatoid arthritis
- breast cancer
- epithelial cancer
- systemic lupus erythematosus
- severe acute respiratory syndrome
- acute coronary syndrome
- ocular sarcoidosis
- pneumonia
- obesity
role in cell
- number
- activation
- cell cycle progression
- differentiation
- function
- quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- cell surface
- cellular membrane
- vesicles
- lysosome
- plasma membrane extracellular face
- Golgi membrane
- trans Golgi network
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2-Aa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- immune response
- peptide antigen assembly with MHC class II protein complex
- adaptive immune response
- positive regulation of immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- late endosome membrane
- clathrin-coated endocytic vesicle membrane
- transport vesicle membrane
- membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- plasma membrane
- endocytic vesicle membrane
- trans-Golgi network membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide antigen binding
- MHC class II receptor activity
- MHC class II protein complex binding