SCYL3 Gene Summary [Human]
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | SCYL3 |
| Official Name | SCY1 like pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:19285] |
| Ensembl ID | ENSG00000000457 |
| Bio databases IDs | |
| Aliases | SCY1 like pseudokinase 3, ezrin-binding partner PACE-1 |
| Synonyms | 1200016D23Rik, 6030457O16, PACE-1, RGD1308992, SCY1-like 3 (S. cerevisiae), SCY1 like pseudokinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCYL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein kinase
- Protein Kinases, catalytic domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCYL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- protein localization
- spinal cord motor neuron differentiation
- neuron development
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- kinase activity