SLC25A5 Gene Summary [Human]

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Details

Type
Protein Coding
Official Symbol
SLC25A5
Official Name
solute carrier family 25 member 5 [Source:HGNC Symbol;Acc:HGNC:10991]
Ensembl ID
ENSG00000005022
Bio databases IDs NCBI: 292 Ensembl: ENSG00000005022
Aliases solute carrier family 25 member 5
Synonyms 2F1, AAC2, Adenine nucleotide translocator 2, Adp, atp carrier, ADP/ATP CARRIER, ADT2, ANC2, ANT2, Fibroblast ATP/ADP Carrier, Slc25a6, solute carrier family 25 member 5, solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5, T2, T3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC25A5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • hydrogen ion transporter
  • ubiquitin protein ligase binding
  • adenine nucleotide transporter
  • Mitochondrial carrier protein
  • protein binding
  • ATP/ADP antiporter
  • adenine transporter
  • transporter
  • oxidative phosphorylation uncoupler

Pathways

Biological processes and signaling networks where the SLC25A5 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • myocardial infarction
  • prostate cancer
  • depressive disorder
  • epithelial cancer
  • breast cancer
  • gout
  • sickle cell anemia
  • pain
  • knee osteoarthritis
  • psoriasis
regulated by
role in cell
  • expression in
  • apoptosis
  • consumption in
  • cell death
  • morphology
  • activation
  • proliferation
  • binding in
  • differentiation
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • myelin enriched fraction
  • mitochondrial envelope
  • cellular membrane
  • inner membrane
  • Nucleus
  • Plasma Membrane
  • Mitochondria
  • mitochondrial nucleoids
  • mitochondrial inner membrane
  • nuclear scaffolds
  • membrane rafts
  • perinuclear focus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC25A5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • erythrocyte differentiation
  • B cell differentiation
  • positive regulation of cell proliferation
  • chromosome segregation
  • adenine nucleotide transport
  • regulation of mitochondrial membrane permeability
  • adenine transport

Cellular Component

Where in the cell the gene product is active
  • MMXD complex
  • nucleus
  • mitochondrial permeability transition pore complex
  • mitochondrion
  • membrane
  • plasma membrane
  • mitochondrial inner membrane
  • mitochondrial nucleoid

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • adenine nucleotide transmembrane transporter activity
  • ubiquitin protein ligase binding
  • protein binding
  • hydrogen ion transmembrane transporter activity
  • ATP:ADP antiporter activity
  • oxidative phosphorylation uncoupler activity
  • adenine transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.