RHBDD2 Gene Summary [Human]
The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. [provided by RefSeq, Sep 2016]
Details
| Type | Processed Transcript |
| Official Symbol | RHBDD2 |
| Official Name | rhomboid domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23082] |
| Ensembl ID | ENSG00000005486 |
| Bio databases IDs | |
| Aliases | rhomboid domain containing 2 |
| Synonyms | 0610011L13RIK, NPD007, RHBDL7, rhomboid domain containing 2, Usmg1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHBDD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Rhomboid family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- Golgi Apparatus
- Mitochondria
- Golgi membrane
- nucleoplasm
- photoreceptor inner segments
- perikaryon
- cone inner segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHBDD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- Golgi membrane
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- signal recognition particle binding