ROMO1 Gene Summary [Human]
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | ROMO1 |
| Official Name | reactive oxygen species modulator 1 [Source:HGNC Symbol;Acc:HGNC:16185] |
| Ensembl ID | ENSG00000125995 |
| Bio databases IDs | |
| Aliases | reactive oxygen species modulator 1, mitochondrial targeting GXXXG protein |
| Synonyms | 2010100O12Rik, bA353C18.2, C20orf52, LOC100910944, LOC683563, MTGM, MTGMP, reactive oxygen species modulator 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ROMO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reactive mitochondrial oxygen species modulator 1
- protein binding
- cation transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ROMO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- replicative senescence
- protein import into mitochondrial matrix
- positive regulation of cell proliferation
- protein import into mitochondrial inner membrane
- intracellular protein transport
- defense response to bacterium
- killing of cells of other organism
- cytolysis by host of symbiont cells
- cellular response to reactive oxygen species
- defense response to Gram-positive bacterium
- positive regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cation transmembrane transporter activity