PDK2 Gene Summary [Human]
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | PDK2 |
| Official Name | pyruvate dehydrogenase kinase 2 [Source:HGNC Symbol;Acc:HGNC:8810] |
| Ensembl ID | ENSG00000005882 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase kinase 2 |
| Synonyms | LOC100506500, PDHK2, PDKII, Pyruvate dehydrogenase kinase 2, pyruvate dehydrogenase kinase, isoenzyme 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- Histidine kinase-like ATPase domain
- [pyruvate dehydrogenase (lipoamide)] kinase
- ATP binding
- protein binding
- identical protein binding
- Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
- kinase
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- binding protein
- protein homodimerization
- Histidine kinase-like ATPases
Pathways
Biological processes and signaling networks where the PDK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- edema
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- Huntington disease
- microvesicular hepatic steatosis
- thermal hyperalgesia
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- expression in
- phosphorylation in
- cell death
- activation
- response by
- gluconeogenesis in
- infiltration by
- glycolysis in
- autophagy in
- depletion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- cellular response to nutrient
- regulation of gluconeogenesis
- protein phosphorylation
- glucose metabolic process
- regulation of pH
- regulation of glucose metabolic process
- signal transduction by p53 class mediator resulting in induction of apoptosis
- glucose homeostasis
- regulation of calcium-mediated signaling
- cellular response to reactive oxygen species
- regulation of cellular ketone metabolic process
- regulation of acetyl-CoA biosynthetic process from pyruvate
Cellular Component
Where in the cell the gene product is active
- pyruvate dehydrogenase complex
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- protein kinase activity
- pyruvate dehydrogenase (acetyl-transferring) kinase activity