GGCT Gene Summary [Human]
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | GGCT |
| Official Name | gamma-glutamylcyclotransferase [Source:HGNC Symbol;Acc:HGNC:21705] |
| Ensembl ID | ENSG00000006625 |
| Bio databases IDs | |
| Aliases | gamma-glutamylcyclotransferase |
| Synonyms | A030007L17RIK, C7orf24, CRF21, gamma-glutamyl cyclotransferase, GCTG, GGC, Ggctl1, RGD1304876, RGD1562590, γ-glutamyl cyclotransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGCT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGCT_like
- gamma-glutamylcyclotransferase
- protein homodimerization
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- breast cancer
- hepatocellular carcinoma
- liver cancer
- prostate cancer
role in cell
- proliferation
- expression in
- number
- quantity
- invasion by
- activation in
- migration
- abnormal morphology
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGCT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- release of cytochrome c from mitochondria
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- gamma-glutamylcyclotransferase activity