DPP3 Gene Summary [Human]
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | DPP3 |
| Official Name | dipeptidyl peptidase 3 [Source:HGNC Symbol;Acc:HGNC:3008] |
| Ensembl ID | ENSG00000254986 |
| Bio databases IDs | |
| Aliases | dipeptidyl peptidase 3, enkephalinase B |
| Synonyms | 4930533O14Rik, dipeptidyl peptidase 3, DPP III |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- peptidase
- dipeptidyl-peptidase III
- Peptidase family M49
- ETGE motif
- dipeptidyl-peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diastolic dysfunction
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- cardiac fibrosis
- lung squamous cell carcinoma
- squamous cell lung cancer
- colorectal cancer
role in cell
- expression in
- cellular infiltration by
- proliferation
- cell viability
- apoptosis
- migration
- activation in
- colony formation by
- number
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein catabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metalloexopeptidase activity
- aminopeptidase activity
- dipeptidyl-peptidase activity