PPP3CC Gene Summary [Human]
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | PPP3CC |
| Official Name | protein phosphatase 3 catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:9316] |
| Ensembl ID | ENSG00000120910 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3 catalytic subunit gamma, calcineurin A gamma, protein phosphatase 2B, catalytic subunit, gamma isoform |
| Synonyms | Calcineurin A gamma, Calcineurin A γ, CALNA3, Calnc, CNA3, CNA gamma, CNA γ, PP2BA gamma, PP2B A-subunit alpha3, PP2BA γ, PP2Bgamma, protein phosphatase 3 catalytic subunit gamma, protein phosphatase 3, catalytic subunit, gamma isoform, protein phosphatase 3 catalytic subunit γ, protein phosphatase 3, catalytic subunit, γ isoform |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP3CC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoprotein phosphatase
- calcium-dependent protein serine/threonine phosphatase
- phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- protein binding
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the PPP3CC gene in human plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- B Cell Receptor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- acute lymphoblastic leukemia
- acute lymphoblastic lymphoma
- diffuse large B-cell lymphoma
- breast cancer
- chronic phase chronic myeloid leukemia
- acute myeloid leukemia
- post transplant diabetes mellitus
- chronic renal failure
- vitiligo
role in cell
- apoptosis
- endocytosis
- dephosphorylation in
- motility
- cycling in
- penetration
- cycling
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- Mitochondria
- cytosol
- sperm midpiece
- sperm tail
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP3CC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- protein dephosphorylation
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of synaptic vesicle endocytosis
Cellular Component
Where in the cell the gene product is active
- calcineurin complex
- protein serine/threonine phosphatase complex
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- calcium-dependent protein serine/threonine phosphatase activity
- calmodulin-dependent protein phosphatase activity
- metal ion binding
- myosin phosphatase activity