ADGRA2 Gene Summary [Human]
Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ADGRA2 |
| Official Name | adhesion G protein-coupled receptor A2 [Source:HGNC Symbol;Acc:HGNC:17849] |
| Ensembl ID | ENSG00000020181 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor A2, tumor endothelial marker 5 |
| Synonyms | 8430414O08Rik, 9530074E10Rik, adhesion G protein-coupled receptor A2, GPR124, mKIAA1531, TEM5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- immunoglobulin domain
- Leucine rich repeat
- GPCR proteolysis site, GPS, motif
- tail domain
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ADGRA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer metastatic to brain
- brain metastasis
- metastatic breast cancer
- disrupted blood brain barrier
- hemolytic anemia
- intraventricular hemorrhage
- central nervous system cancer
- hydrocephalus
- male pattern hair loss
- primary central nervous system lymphoma
regulated by
- JMJD1C
- HK cells
- trans-hydroxytamoxifen
regulates
- Cdc42
- ELMO
role in cell
- activation in
- phosphorylation in
- formation
- formation in
- migration
- adhesion
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of establishment of blood-brain barrier
- sprouting angiogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of angiogenesis
- cell surface receptor signaling pathway
- endothelial cell migration
- negative regulation of vascular endothelial growth factor signaling pathway
- central nervous system development
- canonical Wnt receptor signaling pathway
- regulation of chemotaxis
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- filopodium
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding