NCR3LG1 Gene Summary [Human]
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | NCR3LG1 |
| Official Name | natural killer cell cytotoxicity receptor 3 ligand 1 [Source:HGNC Symbol;Acc:HGNC:42400] |
| Ensembl ID | ENSG00000188211 |
| Bio databases IDs | |
| Aliases | natural killer cell cytotoxicity receptor 3 ligand 1, B7 homolog 6 |
| Synonyms | B7-H6, DKFZp686O24166, LOC107984316, natural killer cell cytotoxicity receptor 3 ligand 1, NKp30L |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCR3LG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- receptor agonist activity
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- non-Hodgkin disease
- atopic dermatitis
- melanoma
- melanoma cancer
- follicular B-cell or T-cell lymphoma
- hepatocellular carcinoma
- mature B-cell neoplasia
- diffuse large B-cell lymphoma
role in cell
- production in
- activation
- cytolysis
- degranulation
- killing
- lysis
- antibody-dependent cell-mediated cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCR3LG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- antibacterial humoral response
Cellular Component
Where in the cell the gene product is active
- immunoglobulin complex, circulating
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- antigen binding
- immunoglobulin receptor binding