PLEKHB1 Gene Summary [Human]
Predicted to enable protein C-terminus binding activity and protein homodimerization activity. Predicted to be involved in regulation of cell differentiation. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLEKHB1 |
| Official Name | pleckstrin homology domain containing B1 [Source:HGNC Symbol;Acc:HGNC:19079] |
| Ensembl ID | ENSG00000021300 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing B1 |
| Synonyms | Evt1, KPL1, PHR1, PHRET1, pleckstrin homology domain containing B1, pleckstrin homology domain containing, family B (evectins) member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLEKHB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain
- PH domain
- protein homodimerization
- E7 binding domain
- protein binding
- Pleckstrin homology-like domain
- membrane-proximal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Golgi membrane
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLEKHB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell differentiation
- phototransduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding