Plekhb1 Gene Summary [Mouse]
Enables protein homodimerization activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Is expressed in central nervous system; sensory organ; and skeleton. Orthologous to human PLEKHB1 (pleckstrin homology domain containing B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhb1 |
| Official Name | pleckstrin homology domain containing, family B (evectins) member 1 [Source:MGI Symbol;Acc:MGI:1351469] |
| Ensembl ID | ENSMUSG00000030701 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family B (evectins) member 1 |
| Synonyms | Evt1, KPL1, PHR1, PHRET1, pleckstrin homology domain containing B1, pleckstrin homology domain containing, family B (evectins) member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain
- PH domain
- protein homodimerization
- E7 binding domain
- protein binding
- Pleckstrin homology-like domain
- membrane-proximal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Golgi membrane
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell differentiation
- phototransduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding